Glycosylated Notch and Cancer

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منابع مشابه

Glycosylated Notch and Cancer

Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural an...

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Notch signaling in cancer.

Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Because perturbations in the regulation of differentiation, survival, and/or proliferation underlie malignant transformation, pathophysiologic Notch signals potenti...

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Notch Signaling, ;-Secretase Inhibitors, and Cancer Therapy

TheNotch signaling pathway represents a critical component in the molecular circuits that control cell fate during development. Aberrant activation of this pathway contributes to tumorigenesis. The role of Notch in human cancer has been highlighted recently by the presence of activating mutations and amplification of Notch genes in human cancer and by the demonstration that genes in the Notch s...

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Notch and VEGF Interactions in Breast Cancer

s Zaghloul, N., Hernandez, S., Tsai, J., Bae, J., Huang, J., Lee, A., Zimmermann, R., Shawber, C.J., Kitajewski, J., Kandel, J.J. and Yamashiro, D.J. Resistance of MYCNAmplified Neuroblastoma Xenografts to VEGF Blockade: Interaction of Notch and VEGF Pathways. (2006) Advances in Neuroblastoma Research, Los Angeles, CA. Shawber, C.J., Francisco, E., Feirt, N., Roe, T., Podgrabinska, S., Kitamura...

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Notch signals spread breast cancer

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ژورنال

عنوان ژورنال: Frontiers in Oncology

سال: 2016

ISSN: 2234-943X

DOI: 10.3389/fonc.2016.00037